Hao-Li Liu received the Ph.D. degrees in Electrical Engineering in 2003 from the National Taiwan University, Taipei, Taiwan. In 2004-2005, He was the research fellow of the Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. He is currently the Distinguished Professor of the Department of Electrical Engineering, Chang-Gung University, Taoyuan, Taiwan, and also the Adjunct Assistant Researcher of Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan. Dr. Liu is currently continuing research in ultrasound thermal therapy and its treatment planning/ simulation, ultrasound-induced blood brain barrier (BBB) disruption for brain drug delivery, ultrasound phased array design. Dr. Liu has published over 130 SCI papers, over 40 worldwide patents been filed in areas of biomedical use of therapeutic ultrasound. Dr. Liu is a member of IEEE and International Society of Therapeutic Ultrasound (ISTU).

Academic appointment:
·2018- present, Distinguished Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan
·2013 – present, Adjunct Researcher, Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan
·2012 – 2015, Director, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan
·2011 – present, Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan
·2008 – 2011, Associate Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan
·2006 – 2012, Adjunct Assistant Researcher, Division of Medical Engineering Research, National Health Research Institutes, Miaoli, Taiwan
·2005 – 2008, Assistant Professor, Department of Electrical Engineering, Chang Gung University, Taoyuan, Taiwan
·2004 –2005, Research Fellow, Focused Ultrasound Laboratory, Department of Radiology, Brigham & Women’s Hospital, Harvard Medical School, MA, USA

Award:
· 2018, Distinguished Research Award (長庚大學優良教師研究獎), Chang-Gung University.
· 2018, Acadamic Research Award, Ministry of Science and Technology (科技部傑出研究獎), Taiwan.
· 2017, Future Technology Breakthrough Award, Ministry of Science and Technology (科技部未來科技突破獎), Taiwan.
· 2017, Lifetime Achievement Award, Albert Nelson Marquis Foundation.
· 2017, Excellent Technology Transfer Award(科技部傑出技轉貢獻獎), Ministry of Science and Technology, Taiwan..
· 2015, The 12th National Innovation Award (生策會第12屆國家新創獎/「學研新創獎」類組) awarded by the Institute for Biotechnology and Medicine Industry
· 2015, Distinguished Research Award (長庚大學優良教師研究獎), Chang-Gung University.
· 2015, TienTe Lee Award (永信李天德醫藥科技獎), awarded by TienTe Lee Biomedical Foundation (永信李天德醫藥基金會) with the category of 「青年醫藥科技奬」, Taiwan.
· 2014, Taiwan Healthcare and Agricultural Biotech Industries Innovation and Excellence Awards, The Epoch Foundation(台灣生醫暨生農選秀大賽/潛力新秀獎首獎)
· 2014, Distinguished Tech-Coop Award (長庚大學優良教師技合獎), Chang-Gung University.
· 2013, Excellent Young Electrical Engineer Award (優秀青年電機工程師獎) from The Chinese Institute of Electrical Engineering, ROC (中國電機工程學會).
· 2013, Frederick Lizzi Early Career Award, International Society for Therapeutic Ultrasound (ISTU).
· 2011, Distinguished Tech-Coop Award (長庚大學優良教師技合獎), Chang-Gung University
· 2011, Wu Ta-You Memorial Award (科技部吳大猷先生紀念獎), National Science Council, Taiwan, 2011.
· 2010, Distinguished Research Award (長庚大學優良教師研究獎), Chang-Gung University.

License：

·  Professional Electrical Engineer, Taiwan (中華民國電機技師 (八十八年電機技師高考及格))

·  Medical Engineer, Taiwan (中華民國醫學工程師 )

 (A)SCI Journal

1.    CJ Lin, CY Lin, YT Lin, CY Huang, KC Wei, JC Chen, GJL Chen, HL Liu*, “Microbubble-Facilitated Ultrasound Pulsation Promotes Direct α-Synuclein Gene Delivery,” Biochemical and Biophysical Research Communications, Vol. 517, No. 1, pp. 77-83, 2019 (*通訊作者; IF = 2.466, 38/375 in“Biophysics”).

2.   CH Wu, HL Liu, CT Ho, PH Hsu, CH Fan, CK Yeh, ST Kang, WS Chen, FN Wang, HH Peng, “Monitoring of acoustic cavitation in microbubble-presented focused ultrasound exposure using gradient-echo magnetic resonance imaging,” Journal of Magnetic Resonance Imaging, Accepted, 2019 (IF=3.732, 26/125 in “Radiology”).

3.   CY Lin, CH Tsai, LY Feng, WY Chai, CJ Lin, CY Huang, KC Wei, CK Yeh, CM Chen, HL Liu, “Focused Ultrasound-Induced Blood Brain-Barrier Opening Enhanced Vascular Permeability for GDNF Delivery in Huntington's Disease Mouse Model,” Brain Stimulation, Accepted, 2019 (*通訊作者; IF=6.919, 22/252 in “Neuroscience”).

4.   KT Chen, KC Wei and HL Liu*, “Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment,” Frontiers in Pharmacology, Vol. 10, pp. 1-16, 2019 (*通訊作者; IF: 3.845, 59/261 in Pharmacology and Pharmacy).

5.  IC Lee, HJ Wu, HL Liu*, “Dual-frequency ultrasound induces neural stem/progenitor cell differentiation and growth factor utilization by enhancing stable cavitation,” ACS Chemical Neuroscience, Vol. 10, pp. 1-18, DOI: 10.1021/acschemneuro.8b00483, 2018 (*通訊作者; IF: 3.861, 83/261 in “Neuroscience”)

6.   HC Tsai, CH Tsai, WS Chen, C Inserra, KC Wei, HL Liu*, "Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening," Scientific Reports, Vol. 8, pp.1-13, 2018. (*通訊作者; IF=4.011, 15/64 in “ Multidisciplinary Sciences”)

7.  HL Liu*, CH Tsai, CK Jan, HY Chang, SM Huang, ML Li, W Qiu, H Zheng, “Design and Implementation of a Dual-Transmit/Receive-Mode Therapeutic Ultrasound Phased Array System for Brain Therapy,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 65 , No. 10, Opp. 1756 – 1767, 2018 (IF = 2.989, 6/31 in “Acoustics”)

8.   SM Huang, HL Liu, DW Li, and ML Li, “Ultrasonic Nakagami Imaging of High-intensity Focused Ultrasound-Induced Thermal Lesions in Porcine Livers: Ex Vivo Study,” Ultrasonic Imaging, Accepted, 2018 (IF = 2.49, 9/31 in“Acoustics”).

9.   PH Hsu, YT Lin, YH Chung, KJ Lin, LY Yang, TC Yen, and HL Liu*, "Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction," Scientific Reports, Vol. 8, pp.1-12, 2018. (*通訊作者; IF=4.011, 15/64 in “ Multidisciplinary Sciences”).

10.  CH Tsai, KT Chen, YX Lin, YC Lin, WS Chen, C Inserra, and HL Liu*, “Acoustic Emission-Feedback Planar Ultrasound System for Localized Blood-Brain Barrier Opening Monitoring, “ Journal of Medical and Biological Engineering, Vol. 39, No. 3, pp. 277-286, 2018 (*通訊作者; SCI IF = 1.306, 66/76 in “Engineering, Biomedical”).

11.  WY Chai, PC Chu, CH Tsai, CY Lin, HW Yang, HY Lai, HL Liu*, “Image-Guided Focused-Ultrasound CNS Molecular Delivery: An Implementation via Dynamic Contrast-Enhanced Magnetic-Resonance Imaging,” Scientific Reports, 7;8(1):4151. doi: 10.1038/s41598-018-22571-8, 2018 (*通訊作者; IF=4.011, 15/64 in “ Multidisciplinary Sciences”). link

12.  ZH Zhou, SC Wu, MY Lin, J Fang, HL Liu*, and PH Tsui*, “Three-dimensional visualization of ultrasound backscatter statistics by window-modulated compounding Nakagami imaging,” Ultrasonic Imaging, Vol. 40, No. 3, pp.171-189, 2018 (*通訊作者; IF = 2.49, 9/31 in“Acoustics”). link

13.  Y Kung, C Lan, MY Hsiao, MK Sun, YH Hsu, APH Liao, WH Liao, HL Liu, C Inserra, WS Chen, “Focused shockwave induced blood-brain barrier opening and transfection,” Scientific Reports, 2218, doi:10.1038/s41598-018-20672-y, 2018 (IF=4.011, 15/64 in “ Multidisciplinary Sciences”). link

14.  MT Tsai, JW Zhang, KC Wei, CK Yeh, HL Liu*, “Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography,” Biomedical Optics Express, Vol. 9, No. 2, pp.507-517, 2018. (IF = 3.91, 15/96 in “Optics”) link

15.   FCM Wu, WH Hsu, HL Liu, T Yonezawa,A Balcytis, S Juodkazis,and K Hatanaka, “Photoacoustic signal enhancements from gold nano-colloidal suspensions excited by a pair of polarized time-delayed femtosecond pulses,” Optics Express, Vol. 25, pp. 19497-19507, 2017 (IF = 3.356, 19/96 in “Optics”).

16.   CH Fan, CY Lin, HL Liu*, and CK Yeh*, “Ultrasound Targeted CNS Gene Delivery for Parkinson’s Disease Treatment,” Journal of Controlled Release, Vol. 261, pp. 246-262, 2017 (*通訊作者; IF = 7.877, 9/256 in “Pharmacology & Pharmacy”).

17.   Lee, JC Yeh, CH Tsai, JT Yang, SL Lou, CJ Seak, CY Wang, KC Wei, HL Liu*, “Improved thrombolytic effect with focused ultrasound and neuroprotective agent against acute carotid artery thrombosis in rat,” Scientific Reports, 7(1):1638. doi: 10.1038/s41598-017-01769-2., 2017. (*通訊作者; IF=4.122, 16/64 in “ Multidisciplinary Sciences”).  

18.   SK Wu, PC Chu, WY Chai, ST Kang, CH Tsai, CH Fan, CK Yeh, HL Liu*, “Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening,” Scientific Reports, 7:46689. doi: 10.1038/srep46689., 2017. (*通訊作者; IF=4.122, 16/64 in “ Multidisciplinary Sciences”)

19.   PY Chen, CK Yeh, PH Hsu, CY Lin, CY Huang, KC Wei, HL Liu*, “Drug-carrying Microbubbles as a Theranostic Tool in Convection-Enhanced Delivery for Brain Tumor Therapy,” Oncotarget, Vol. 8, No. 26, pp.42359-42371, 2017. (*通訊作者; IF = 5.168, 44/217 in "Oncology") link

20.   P Rwei, CSA Gong, LJ Luo, MB Lin, JY Lai*, HL Liu*, “In vitro investigation of ultrasound-induced oxidative stress on human lens epithelial cells,” Biochemical and Biophysical Research Communications, Vol. 482, pp.954-960, 2017 (*通訊作者; IF = 2.466, 38/375 in “Biophysics”). link

21.   HH Peng, CH Wu, ST Kang, JW Zhang, HL Liu, WS Chen, CH Wang, CK Yeh, “Real-Time Monitoring of Inertial Cavitation Effects of Microbubbles by Using MRI: In Vitro Experiments,” Magnetic Resonance in Medicine, Vol. 77, No. 1, pp.102-111, 2017 (IF=4.082, 19/126 in “Radiology”) link

22.   MT Tsai, JW Zhang, YH Liu, CK Yeh, KC Wei, and HL Liu*, “Acoustic-actuated optical coherence angiography,” Optics Letters, Vol. 41, pp. 5813-5816, 2016 (*通訊作者; IF = 3.589, 14/96 in "Optics") link

23.   PC Chu, Wen-Yen Chai, CH Tsai, ST Kang, CK Yeh and HL Liu*, “Focused Ultrasound-Induced Blood-Brain Barrier Opening: Association with Mechanical Index and Cavitation Index Analyzed by Dynamic Contrast-Enhanced Magnetic-Resonance Imaging,” Scientific Reports, 6:33264, doi: 10.1038/srep33264, 2016 (*通訊作者; IF=4.122, 16/64 in “ Multidisciplinary Sciences”). link

24.   FCP Masim, WH Hsu, CH Tsai, HL Liu, M Porta, MT Nguyen, T Yonezawa, A Balcytis, X Wang, S Juodkazis, and K Hatanaka, “MHz-ultrasound generation by chirped femtosecond laser pulses from gold nano-colloidal dispersions,” Optics Express, Vol. 24, No. 15, pp. 24050-24059, 2016 (IF = 3.356, 19/96 in “Optics”) link

25.   FCP Masim, HL Liu, M Porta, T Yonezawa, A Balcytis, S Juodkazis, WH Hsu, and K Hatanaka, “Enhanced photoacoustics from gold nano-colloidal suspensions under femtosecond laser excitation,” Optics Express, Vol. 24, No. 13, pp.14781-14792, 2016 (IF = 3.356, 19/96 in “Optics”) link

26.   J Xia, PH Tsui, HL Liu*, “Low-Pressure Burst-Mode Focused Ultrasound Wave Reconstruction and Mapping for Blood-Brain Barrier Opening: A Preclinical Examination,” Scientific Reports, 6:27939, doi:10.1038/srep27939., 2016 (*通訊作者; IF=4.122, 16/64 in “ Multidisciplinary Sciences”). link

27.   YW Chen, TY Liu, PH Chang, PH Hsu, HL Liu, HC Lin, SY Chen, “A theranostic nrGO@MSN-ION nanocarrier developed to enhance the combination effect of sonodynamic therapy and ultrasound hyperthermia for treating tumor,” Nanoscale, Vol. 8, No. 25, pp.12648-57, 2016. (IF = 7.233, 25/165 in “Chemistry, Multiplidiciplinary”)

28.   CY Lin, HY Hsieh, CM Chen, SR Wu, CH Tsai, CY Huang, MY Hua, KC Wei, CK Yeh, and HL Liu*, "Non-invasive, Neuron-Specific Gene Therapy by Focused Ultrasound-Induced Blood-Brain Barrier Opening in Parkinson’s Disease Mouse Model", Journal of Controlled Release, Vol. 235, pp. 72-81,2016 (*通訊作者; IF = 7.877, 9/256 in “Pharmacology & Pharmacy”) link

29.   SS Li, CW Lin, KC Wei, CY Huang, PH Hsu, HL Liu, YJ Lu, SC Lin, HW Yang*, CCM Ma*, “Non-invasive screening for early Alzheimer's disease diagnosis by a sensitively immunomagnetic biosensor”, Scientific Reports, 6:25155. doi:10.1038/srep25155., 2016 (IF=5.228, 7/63 in “ Multidisciplinary Sciences”). link

30.   CH Fan, YH Cheng, CY Ting, YJ Ho, PH Hsu, HL Liu*, CK Yeh*, “Ultrasound/Magnetic Targeting with SPIO-DOX-Microbubble Complex for Image-Guided Drug Delivery in Brain Tumors,” Theranostics, Vol. 6, No. 10, pp.1542-1556, 2016 (*通訊作者; IF = 8.537, 8/128 in “Medicine, Research and Experimental”). link

31.   MT Tsai, IC Lee, ZF Lee, HL Liu, YC Choia, CC Wang, JD Lee1*, “In vivo evaluation of temporal effects and drug delivery induced by transdermal microneedles with optical coherence imaging,” Biomedical Optics Express, Vol. 7, No. 5, pp. 1865-1876, 2016 (IF = 3.482, 15/96 in “Optics”). link

32.   HL Liu, PH Hsu, CY Lin, CW Huang, WY Chai, PC Chu, CY Huang, PY Chen, LY Yang, JS Kuo, KC Wei*, “Focused Ultrasound Enhances CNS Delivery of Bevacizumab for Malignant Glioma Treatment,” Radiology, Vol. 281, pp. 99-108, 2016 (IF=7.469, 4/126 in“Radiology”). link

33.   CH Tsai, JW Zhang, YY Liao, HL Liu*, “Real-time monitoring of focused ultrasound blood-brain barrier opening via subharmonic acoustic emission detection: Implementation of confocal dual-frequency piezoelectric transducers,” Physics in Medicine and Biology, Vol. 61, pp. 2926-2946, 2016 (*通訊作者; IF = 2.665, 27/77 in “Engineering, Biomedical”) link

34.   CH Fan, CY Ting, CY Lin, HL Chan, YC Chang, YY Chen, HL Liu*, and CK Yeh*, “Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson's Disease,” Scientific Reports, 6:19579. doi:10.1038/srep19579, 2016 (*通訊作者; IF=4.122, 16/64 in “ Multidisciplinary Sciences”). link

35.   PC Chu**, HL Liu**, HY Lai, CY Lin, HC Tsai, YC Pei, "Neuromodulation accompanying focused ultrasound-induced blood-brain barrier opening," Scientific Reports, Vol. 5: 15477, 2015 (**Equal Contribution; IF=5.228, 7/63 in “ Multidisciplinary Sciences”). link

36.   PY Chen, KC Wei, HL Liu*, “Neural Immune Modulation and Immunotherapy Assisted by Focused Ultrasound Induced Blood-Brain Barrier Opening", Human Vaccines & Immunotherapeutics, Vol. 11, no. 10, accepted, 2014 (*通訊作者; IF = 2.157, 79/161 in “Biotechnology & Applied Microbiology”). link

37.   CY Lin, HY Hsieh, WG Pitt, CY Huang, IC Tseng, CK Yeh, KC Wei, HL Liu*, “Focused Ultrasound-Induced Blood-Brain Barrier Opening for Non-Viral, Non-invasive, and Targeted Gene Delivery,” Journal of Controlled Release, Vol. 212, pp.1-9, 2015 (*通訊作者; IF = 7.877, 9/256 in “Pharmacology & Pharmacy”) link (Selected as “Cover story” of the issue)

38.   AH Liao, HY Chou, YL Hsieh, SC Hsu, KC Wei, and HL Liu*, “Enhanced Therapeutic Epidermal growth factor receptor (EGFR) Antibody Delivery via Pulsed Ultrasound with Targeting Microbubbles for Glioma Treatment,” Journal of Medical and Biological Engineering, Vol. 1, pp. 1-9, Eng. DOI 10.1007/s40846-015-0032-9, 2014 (SCI IF = 1.211, 55/76 in “Engineering, Biomedical”). link (Selected as “The paper of the year in JMBE”)

39.   PY Chen, HY Hsieh, CY Huang, CY Lin, KC Wei, and HL Liu*, “Focused Ultrasound-Induced Blood-Brain Barrier Opening to Enhance Interleukin-12 Delivery for Brain Tumor Immunotherapy: A Preclinical Feasibility Study,” Journal of Translational Medicine, Vol. 13, No. 93, pp. 1-12, 2015 (*Corresponding author; IF = 4.197, 28/128 in “Medicine, Res. & Exp”). link

40.   CH Fan, CY Ting, YC Chang, KC Wei, HL Liu*, and CK Yeh*, "Drug-loaded Bubbles with Matched Focused Ultrasound Excitation for Concurrent Blood-Brain Barrier Opening and Brain-Tumor Drug Delivery," Acta Biomaterialia, Vol. 15, pp. 89–101, 2015 (*Corresponding author; IF = 6.383, 3/78 in “Engineering, Biomedical”) link

41.   HY Huang**, HL Liu**, PH Hsu, CS Chiang, CH Tsai, HS Chi, SY Chen, and YY Chen*, “Multitheragnostic Nanobubble System to Induce Brain-Blood Barrier Disruption with Magnetically Guided Focused Ultrasound,” Advanced Materials, Vol. 27, pp. 655-661, 2015 (**Equal Contribution; IF=21.95, 5/165 in “Chemistry, Multidisciplinary”) link

42.   HL Liu*, CY Huang, JY Chen, HYJ Wang, PY Chen, and KC Wei, “Pharmacodynamic and Therapeutic Investigation of Focused Ultrasound-induced Blood-Brain Barrier Opening for Enhanced Temozolomide Delivery in Glioma Treatment,” PLoS ONE, Vol. 9, No. 12, e114311, 2014 (SCI IF = 2.766, 15/64 in “Multidisciplinary Sciences”) link (Highlight by Neurosurgery)

43.   KJ Chen, EY Chaung, SP Wey, KJ Lin, F Cheng, CC Lin, HL Liu, HW Tseng, CP L, MC W, CM Liu, and HW Sung, "Hyperthermia-Mediated Local Drug Delivery by a Bubble-Generating Liposomal System for Tumor-Specific Chemotherapy,” ACS Nano, Vol. 8, No. 5, pp. 5105-5115, 2014 (IF=13.7, 10/163 in “Chemistry, Multidisciplinary”). link

44.   MT Tsai, FY Chang, CK Lee, CS Gong, YX Lin, JD Lee, CH Yang, HL Liu*, “Investigation of temporal vascular effects induced by focused ultrasound treatment with speckle-variance optical coherence tomography,” Biomedical Optics Express. Vol. 5, No. 7, pp. 2009-22, 2014. (*Corresponding author; IF = 3.482, 15/96 in “Optics”). link

45.   CH Fan, WH Lin, CY Ting, WY Chai, TC Yen, HL Liu* and CK Yeh*, “Contrast-Enhanced Ultrasound Imaging for the Detection of Focused Ultrasound-Induced Blood-Brain Barrier Opening,” Theranostics, Vol. 4, No. 10, pp. 1014-1025, 2014 (*Corresponding author; IF = 8.537, 8/128 in “Medicine, Research and Experimental”). link

46.   WY Chai, PC Chu, MY Tsai, YC Lin, JJ Wang, KC Wei, YY Wai and HL Liu*, “Magnetic-Resonance Imaging for Kinetic Analysis of Permeability Changes during Focused Ultrasound-Induced Blood-Brain Barrier Opening and Brain Drug Delivery,” Journal of Controlled Release, Vol. 192, pp.1-9, 2014 (SCI IF = 7.877, 9/256 in “Pharmacology & Pharmacy”) link

47.   J Xia, Q Li,PY Chen, Z Zhou,CY Wang, HL Liu, J Teng, and PH Tsui, "Considering Angle Selection When Using Ultrasound Electrode Displacement Elastography to Evaluate Radiofrequency Ablation of Tissues," BioMed Research International, Volume 2014, ID 764320, 2014 (IF = 2.476, 81/161 in "Biotech. and App. Microbiology")

48.   CH Fan**, HL Liu**, CY Ting, YH Lee, CY Huang, YJ Ma, KC Wei, TC Yen and CK Yeh, “Submicron-Bubble-Enhanced Focused Ultrasound for Blood–Brain Barrier Disruption and Improved CNS Drug Delivery,” PLoS ONE, Vol.9, No. 5, e96327, 2014 (**Equal contribution, SCI IF = 2.766, 15/64 in “Multidisciplinary Sciences”) link

49.   X Geng, Z Zhou, Q Li, S Wu, CY Wang, HL Liu, CC Chuang, and PH Tsui, “Comparison of ultraosund temperature imaging with infrared thermometry during radio frequency ablation,” Japanese Journal of Applied Physics, Vol. 53, No. 4, pp. 047001, 2014 (IF = 1.122, 97/145 in Phycis, Applied)

50.   HL Liu*, CK Jan, PC Chu, JC Hong, PY Lee, JD Hsu, CC Lin, CY Huang, PY Chen, and KC Wei*, “Design and Experimental Evaluation of a 256-Channel Dual-Frequency Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Opening and Brain Drug Delivery,” IEEE Transactions on Biomedical Engineering, Vol. 61, No. 4, pp.1350-1360, 2014 (IF=4.288, 9/78 in “Engineering, Biomedical”). link

51.   HL Liu, CH Fan, CY Ting, and CK Yeh, "Combining Microbubbles and Ultrasound for Drug Delivery to Brain Tumors" Theranostics, Vol. 4, No. 4, pp.432-444, 2014 (IF = 8.537, 8/128 in “Medicine, Research and Experimental”). link

52.   HW Yang, CY Huang, CW Lin, HL Liu, CW Huang, SS Liao, PY Chen, PW Hsu, YJ Lu, KC Wei, CCM Ma, “Gadolinium-functionalized nanographene oxide as a nanocarrier for combined drug and microRNA delivery and magnetic resonance imaging,” Biomaterials, Vol., 35, No. 6534-42, 2014 (IF = 8.806, 1/78 in “Engineering, Biomedical”). link

53.   JJ Xia, Q Li, HL Liu, WS Chen and PH Tsui, "An Approach for the Visualization of Temperature Distribution in Tissues According to Changes in Ultrasonic Backscattered Energy," Computational and Mathematical Methods in Medicine, Volume 2013, Article ID 682827 (IF = 0.766).

54.   YW Huang, SH Hu, SY Hung, CS Chiang, HL Liu, TL Chiou, HY Lai, YY Chen, "SPIO Nanoparticle-Stabilized Nanobubbles with MR/US Dual-Modality Imaging and HIFU-triggered Release Drug for in-vivo Therapy," Journal of Controlled Release, Vol. 172, pp.118-127, 2013 (IF = 7.786, 10/256 in "Chemistry, Multidisciplinary). link

55.   HW Yang, YJ Lu, KJ Lin, SC Hsu, CY Huang, SH She, HL Liu, MC Xiao, SP Wey, PY Chen, TC Yen, KC Wei, CCM Ma, "EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy, " Biomaterials, Vol. 34, No. 29, pp. 7204-7214, 2013 IF = 8.806, 1/78 in “Engineering, Biomedical”). link

56.   MT Tsai, CK Lee, KM Lin, YX Lin, TH Lin, TC Chang and HL Liu*, "Quantitative Observation Evaluation of Focused Ultrasound Induced Vascular Leakage and Deformation after Focused Ultrasound Treatment Exposure via by using Fluorescein Angiography and Optical Coherence Tomography," Journal of Biomedical Optics, Vol.18, No. 10, pp.101307, 2013 (IF=2.53, 30/92 in “Optics”). link

57.   CY Wang, TS Yeh, XN Geng, HL Liu, and PH Tsui, "Monitoring Radiofrequency Ablation with Ultrasound Nakagami Imaging," Medical Physics, Vol.40, No.7, pp.072901, 2013. (IF=2.884, 36/126 in “Radiology”).

58.   H.W. Yang, M.Y. Hua, T.L. Hwang, K.J. Lin, C.Y. Huang, R.Y. Tsai, C.C.M. Ma, P.H. Hsu, S.P. Wey, P.W. Hsu, P.Y. Chen, Y.C. Huang, Y.J. Lu, T.C. Yen, L.Y. Feng, C.W. Lin, H.L. Liu*, K.C. Wei*. “Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide,” Advanced Materials, Vol. 25, No. 26, pp.3605-3611, 2013. (*Corresponding author; IF=21.95, 5/165 in “Chemistry, Multidisciplinary”). link

59.   HW Yang, HL Liu**, ML Li, IW Hsi, CT Fan, CY Huang, YJ Lu, MY Hua, HY Chou, JW Liaw, CCM Ma and KC Wei, "Magnetic gold-nanorod/ PNIPAAmMA nanoparticles for dual magnetic resonance and photoacoustic imaging and targeted photothermal therapy," Biomaterials, Vol. 34, pp.5651-5660, 2013. (**共同第一作者; IF = 8.806, 1/78 in “Engineering, Biomedical”). link

60.   PC Chu, WY Chai, HY Hsieh, JJ Wang, SP Wey, CY Huang, KC Wei and HL Liu*, "Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors," BioMed Research International, Vol. 2013, pp. 627496, 2013 (*通訊作者; IF = 2.476, 81/161 in "Biotech. and App. Microbiology").link

61.   KC Wei, PC Chu, HYJ Wang, CY Huang, PY Chen, HC Tsai, YJ Lu, IC Tseng, PY Lee, TC Yen, and HL Liu*, "Focused Ultrasound-induced Blood–Brain Barrier Opening to Enhance Temozolomide Delivery for Glioblastoma Treatment: A Preclinical Study, " PLoS ONE, Vol. 8, No. 3, pp. e58995, 2013 (*通訊作者; SCI IF = 2.766, 15/64 in “Multidisciplinary Sciences”) link

62.   C-H Fan, C-Y Ting, H-J Lin, C-H Wang, H-L Liu*, T-C Yen, C-K Yeh*, "SPIO-Conjugated, Doxorubicin-Loaded Microbubbles for Concurrent MRI and Focused-Ultrasound Enhanced Brain-Tumor Drug Delivery," Biomaterials, Vol. 34, pp. 3706-3715, 2013 (*共同通訊作者; IF = 8.806, 1/78 in “Engineering, Biomedical”) link

63.   P-H Hsu, K-C Wei, C-Y Huang, C-J Wen, T-C Yen, C-L Liu, Y-T Lin, J-C Chen, C-R Shen, and H-L Liu*, "Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound, " PLoS ONE, Vol. 8, No. 2, pp. e57682, 2013 (*通訊作者; SCI IF = 3.234, 8/56 in " Multidisciplinary Sciences ") link

64.   K.J. Chen, H.F. Liang, H.L. Chen, Y.C. Wang, P.Y. Cheng, H.L. Liu, Y.N. Xia, H.W. Sung, "A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery", ACS Nano, Vol. 7, No. 1, pp. 438-446, 2013 (IF=13.334, 8/163 in “Chemistry, Multidisciplinary”). link

65.   C-H Fan, C-Y Ting, H-L Liu*, C-Y Huang, H-Y Hsieh, T-C Yen, K-C Wei, C-K Yeh, "Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment, " Biomaterials, Vol. 34, pp. 2142-2155, 2013 (*共同通訊作者; IF = 8.806, 1/78 in “Engineering, Biomedical”). link

66.   K-C Wei, H-C Tsai, Y-J Lu, H-W Yang, M-Y Hua, M-F Wu, P-Y Chen, C-Y Huang, T-C Yen, and H-L Liu*, “Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening: A Preliminary Study in Swine,” American Journal of Neuroradiology, Vol. 34, No. 1, pp. 115-120, 2013. (IF=3.55, 24/124 in “Radiology”) link

67.   H-L Liu, H-Y Hsieh, L-A Lu, C-W Kang, M-F Wu and C-Y Lin, "Low-Pressure Pulsed Focused Ultrasound with Microbubbles Promotes an Anticancer Immunological Response," Journal of Translational Medicine, Vol. 10: 221, 2012 (IF = 3.786, 30/128 in "Medicine, Res. & Exp") link

68.   H-W Yang, M-Y Hua, K-J Lin, S-P Wey, R-Y Tsai, S-Y Wu, Y-C Lu, H-L Liu, Tony Wu, Y-H Ma, “Bioconjugation of recombinant tissue plasminogen activator to magnetic nanocarriers for targeted thrombolysis,” International Journal of Nanomedicine, Vol. 7, pp. 1–11, 2012 (IF = 4.3, 26/83 in "Nanoscience & Nanotechnology").

69.   H-W Yang, M-Y Hua, H-L Liu, C-Y Huang, K-C Wei, “Potential of magnetic nanoparticles for targeted drug delivery.” Nanotechnology, Science and Applications, Vol. 5, pp. 73-86, 2012 (SCI).

70.   A-H Liao, Y-K Li, W-J Lee, M-F Wu, H-L Liu, and M-L Kuo, “Estimating the Delivery Efficiency of Drug-Loaded Microbubbles in Cancer Cells with Ultrasound and Bioluminescence Imaging,” Ultrasound in Medicine and Biology, Vol. 38, No. 11, pp. 1938–1948, 2012 (IF=2.645, 7/32 in “Acoustics”).

71.   P-H Liao, H-H Yang, P-T Chou, M-H Wang, P-C Ju, H-L Liu, and L-K Chen, "Sufficient virus-neutralizing antibody in the central nerve system improves the survival of rabid rats," Journal of Biomedical Sciences, Vol. 19: 61, 2012 (IF = 1.98)

72.   Y-H Ma, S-Y Chen, S-J Tu, H-W Yang, H-L Liu, “Manipulation of magnetic nanoparticle retention and hemodynamic consequences in microcirculation: assessment by laser speckle imaging,” International Journal of Nanomedicine, Vol. 7, pp. 1–11, 2012 (IF = 4.3, 26/83 in "Nanoscience & Nanotechnology")

73.   C-J Ke, Y-J Lin, Y-C Hua, W-L Chiang, K-J Chen, W-C Yang, H-L Liu, C-C Fu, H-W Sung, “Multidrug release based on microneedle arrays filled with pH-responsive PLGA hollow microspheres,” Biomaterials, Vol. 33, No. 20, pp. 5156-5165, 2012. (IF = 8.806, 1/78 in “Engineering, Biomedical”).

74.   A-H Liao, H-L Liu**, C-H Su, M-Y Hua, H-W Yang, Y-T Weng, P-H Hsu, S-M Huang, S-Y Wu, H-El Wang, T-C Yen and P-C Li, “Paramagnetic Perfluorocarbon-Filled Albumin-(Gd-DTPA) Microbubbles for the Induction of Focused-Ultrasound-Induced Blood–Brain Barrier Opening and Concurrent MR and Ultrasound Imaging,” Physics in Medicine and Biology, Vol. 57, pp.2787-2802, 2012 (**共同第一作者; IF = 2.665, 27/77 in “Engineering, Biomedical”) link

75.   P-H Tsui, Y-C Shu, W-S Chen, H-L Liu, I-T Hsiao, and Y-T Chien, "Ultrasound temperature estimation based on probability variation of backscatter data", Medical Physics, Vol. 39, No. 5, pp. 2369-2385, 2012 (IF=2.884, 36/126 in “Radiology”).

76.   P-H Wang**, H-L Liu**, P-H Hsu, C-R C Wang, P-Y Chen, K-C Wei, T-C Yen, and M-L Li, "Gold-nanorod contrast-enhanced photoacoustic micro-imaging of focused- ultrasound induced blood-brain barrier opening in a rat model", Journal of Biomedical Optics, Vol. 17, No. 6, pp. 061222, 2012 (**共同第一作者; IF= 2.556, 21/90 in “Optics”). link

77.   C-H Fan, H-L Liu, C-Y Huang, Y-J Ma, T-C Yen, C-K Yeh, “Detection of intracerebral hemorrhage and transient blood-supply shortage in focused ultrasound-induced blood-brain-barrier disruption by ultrasound imaging,” Ultrasound in Medicine and Biology, Vol. 38, No. 8, pp. 1372–1382, 2012 (IF=2.645, 7/32 in “Acoustics”). link

78.   P-H Tsui, Y-T Chien, H-L Liu, Y-C Shu, W-S Chen, “Using ultrasound CBE imaging without echo shift compensation for temperature estimation,” Ultrasonics, Vol. 52, No. 7, pp. 925-935, 2012. (IF=1.954, 8/32 in “Acoustics”)

79.   H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, S-T Pang, P-H Hsu, H-J Tang, T-C Yen, C-K Chuang, “An epirubicin-conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer,” Biomaterials, Vol. 33, pp. 3919-3930, 2012. (**共同第一作者; IF = 8.806, 1/78 in “Engineering, Biomedical”). link

80.   H-W Yang**, M-Y Hua**, H-L Liu**, R-Y Tsai, C-K Chuang, P-C Chu,P-Y Wu, Y-H Chang, H-C Chuang, K-J Yu, and S-T Pang, “Cooperative dual-activity targeted nanomedicine for specific and effective prostate cancer therapy”, ACS Nano, Vol.6, No. 2, pp1795-1805, 2012 (**共同第一作者; IF=13.334, 8/163 in “Chemistry, Multidisciplinary””). link

81.   Y-C Lin, T-H Chan, C-Y Chi, S-H Ng, H-L Liu, K-C Wei, Y-Y Wei, C-C Wang, J-J Wang, “Blind Estimation of Arterial Input Function in Dynamic Contrast-Enhanced MRI using Purity Maximization,” Magnetic Resonance in Medicine, Vol. 68, No. 5, pp. 1439-1449, 2012 (IF=4.082, 19/126 in “Radiology”)

82.   H-L Liu, H-W Yang, M-Y Hua, and K-C Wei, “Enhanced Therapeutic Agent Delivery via MRI-Monitored Focused Ultrasound Blood-Brain Barrier Disruption for Brain Tumor Treatment: An Overview of the current Preclinical Status,” Neurosurgical Focus, Vol. 32, No. 1, E4, 2012 (IF = 3.139, 39/196 in “Surgery”). link

83.   C-Y Ting, C-H Fan, H-L Liu*, C-Y Huang, H-Y Hsieh, T-C Yen, K-C Wei, C-K Yeh*, “Concurrent blood-brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment,” Biomaterials, Vol. 33, pp. 704-712, 2012 (*Co-corresponding author, IF = 8.806, 1/78 in “Engineering, Biomedical”). link

84.   M-T Tsai, T-D Chi, H-L Liu, F-Y Chang, C-H Yang, C-K Lee, and C-C Yang, “Microvascular imaging using swept-source optical coherence tomography with single-channel acquisition,” Appl. Phys. Express, Vol. 4, pp.097001-3, 2011 (IF =2.365, 21/125 in “Physics, Applied”).

85.   W-S Chen, H-L Liu, Y.S. Tung, J.C. Wang, Y.H. Ding, C.K. Jan, “Reducing lesion aberration by dual-frequency focused ultrasound ablations,” International Journal of Hyperthermia, Vol. 27, No. 7, pp. 637-647, 2011 (IF=2.645, 37/125in “Radiology”).

86.   C-J Ke, T-Y Su, H-Chen, H-L Liu, W-L Chiang, P-C Chu, Y Xia, H-W Sung, “Smart Multifunctional Hollow Microspheres for the Quick Release of Drugs in Intracellular Lysosomal Compartments,” Angewandte Chemie International Edition, Vol. 50, No. 35, pp. 8086 – 8089, 2011 (IF = 11.994, 13/157 in “Chemistry, Multidisciplinary”)

87.   M-Y Hua**, H-W Yang**, H-L Liu**, R-Y Tsai, S-T Pang, K-L Chuang, Y-S Chang, T-L Hwang, Y-H Chang, H-C Chuang, C-K Chuang, “Superhigh-magnetization nanocarrier as a doxorubicin delivery platform for magnetic targeting therapy,” Biomaterials, Vol. 32, pp. 8999-9910, 2011 (**共同第一作者, IF = 8.806, 1/78 in “Engineering, Biomedical”). link

88.   J-J Wang , W-Y Lin, C-S Lu, Y-H Weng, S-H Ng , C-H Wang , H-L Liu, R-H Hsieh , Y-L Wan, and Y-Y Wai, “Parkinson Disease_Diagnostic Utility of Diffusion Kurtosis Imaging,” Radiology, Vol. 261, No. 1, pp. 210-217 (IF=7.469, 4/126 in“Radiology”).

89.   H-L Liu, P-Y Chen, H-W Yang, J-S Wu, I-C Tseng, Y-J Ma, C-Y Huang, H-C Tsai,  S-M Chen, Y-J Lu, C-Y Huang, M-Y Hua, Y-H Ma, T-C Yen and K-C Wei, “In Vivo MR Quantification of Superparamagnetic Iron Oxide Nanoparticle Leakage During Low-frequency-ultrasound–induced Blood–Brain Barrier Opening In Swine,” Journal of Magnetic Resonance Imaging, Vol. 34, No. 12, pp. 1313-1324, 2011 (IF=3.083, 23/125 in “Radiology”). link

90.   H-W Yang**, M-Y Hua**, H-L Liu**, C-Y Huang, R-Y Tsai, Y-J Lu, J-Y Chen, H-J Tang, H-Y Hsien, Y-S Chang, T-C Yen, P-Y Chen and K-C Wei, “Self-protecting core-shell magnetic nanoparticles for targeted, traceable, long half-life delivery of BCNU to gliomas,” Biomaterials, Vol. 32, pp. 6523-6532, 2011 (**共同第一作者, IF = 8.806, 1/78 in “Engineering, Biomedical”). link

91.   W-S Chen, C-C Shen, C-T Ko, C-H Cheng, H-L Liu, M-C Ho, C-N Chen, C-K Yeh, “Single-Element Ultrasound Transducer for Combined Vessel Localization and Ablation,” IEEE Trans. Ultrason. Ferroelectrics Freq. Contr., Vol. 58, No. 4, pp. 766-775, 2011 (IF = 1.512, 10/31 in “Acoustics”)

92.   H-L Liu, M-L Li, P-H Tsui, M-S Lin, S-M Huang, and J Bai, “An Unified Approach to Combine Temperature Estimation and Elastography for Thermal Lesion Determination in Focused Ultrasound Thermal Therapy,” Physics in Medicine and Biology, Vol. 56, pp. 169-186, 2011. (IF = 2.665, 27/77 in “Engineering, Biomedical”) link

93.   M-Y Hua**, H-L Liu**, H-W Yang, P-Y Chen, R-Y Tsai, C-Y Huang, I-C Tseng, L-A Lyu, C-C Ma, H-J Tang, T-C Yen, K-C Wei, “The effectiveness of a magnetic-nanoparticle-based delivery system for BCNU in the treatment of gliomas,” Biomaterials, Vol. 32, pp. 512-523, 2011 (**共同第一作者, IF = 8.806, 1/78 in “Engineering, Biomedical”). link

94.   H-L Liu, S-M Huang, and M-L Li, “High frame rate ultrasound monitoring of high intensity focused ultrasound induced temperature changes: a novel asynchronous approach,” Medical Physics, Vol. 37, No. 11, pp. 5921-5928, 2010 (IF=2.884, 36/126 in “Radiology”). link

95.   H-L Liu, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, J-S Wua, I-C Tseng, J-J Wang, T-C Yen, P-Y Chen, and K-C Wei, “Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain,” Proceedings of National Academy of Science USA, Vol. 107, No. 34, pp.15205-15210, 2010 (IF=9.504, 5/74 in “Multidisciplinary sciences”). link

96.   K-C Ju and H-L Liu, “Zero-crossing-tracking technique for noninvasively ultrasonic temperature estimation,” Journal of Ultrasound in Medicine, Vol. 29, pp.1607–1615, 2010 (IF=1.402, 13/31 in “Acoustics”).

97.   P-Y Chen**, H-L Liu**, M-Y Hua, H-W Yang, C-Y Huang, P-C Chu, L-A Lyu, H-C Tsai, S-M Chen, Y-J Lu, J-J Wang, T-C Yen, Y-H Ma, T. Wu, J-P Chen, J-I Chuang, J-W Shin, C. Hsueh, and K-C Wei, “Novel Magnetic/Ultrasound Focusing System Enhances Nanoparticle Drug Delivery for Glioma Treatment,” Neuro-oncology, Vol. 12, No. 10, pp.1050-1060, 2010 (**共同第一作者, IF=9.384, 15/194 in “Clinical Neurology”). link

98.   H-L Liu, M-Y Hua, P-Y Chen, P-C Chu, C-H Pan, H-W Yang, C-Y Huang, J-J Wang,  T-C Yen and K-C Wei, “Blood–Brain Barrier Disruption by Focused Ultrasound Enhances Delivery of Chemotherapeutic Drugs for Glioblastoma Treatment,” Radiology, Vol. 255, No. 2, pp. 415-425, 2010 (IF=7.469, 4/126 in“Radiology”) link

99.   H-L Liu, C-L Hsu, S-M Huang and Y-W Hsi, “Focal Beam Distortion and Treatment Planning for Transrib Focused Ultrasound Thermal Therapy: A Feasibility Study Using a Two-dimensional Ultrasound Phased Array,” Medical Physics, Vol. 37, No. 2, pp. 848-860, 2010 (IF=2.884, 36/126 in “Radiology”).link

100. H-L Liu, C-H Pan, C-Y Ting and M-J Hsiao, “Opening of the Blood-Brain Barrier By Low-Frequency (28-kHz) Ultrasound: A Novel Pinhole-Assisted Mechanical Scanning Device,” Ultrasound in Medicine and Biology, Vol. 36, No. 2, pp. 325-335, 2010 (IF=2.645, 7/32 in “Acoustics”). link

101.  Y-C Lin, C-C Wang, Y-Y Wai, Y-L Wan,S-H Ng, Y-L Chen, H-L Liu, J-J Wang, “Significant temporal evolution of diffusion anisotropy for evaluating of early response to radiosurgery in patients with vestibular schwannoma: findings from functional diffusion maps,” American Journal of Neuroradiology, Vol. 31, pp. 269-274, 2010. (IF=3.55, 24/124 in “Radiology”)

102.  H-L Liu, Y-Y Wai, P-H Hsu, L-A Lyu, J-S Wu, C-R Shen, J-C Chen, T-C Yen, and J-J Wang, “In Vivo Assessment of Macrophage CNS Infiltration during Disruption of the Blood–brain Barrier with Focused Ultrasound: A Magnetic Resonance Imaging Study,” Journal of Cerebral Blood Flow & Metabolism, Vol. 30, pp. 168-177, 2010 (IF=5.081, 33/252 in “Neuroscience”). link

103.   J-J Wang, Y-Y Wai, Y-H Weng, K-K Ng, Y-Z Huang; L. Ying, H-L Liu, and C-H Wang, “Functional MRI in the assessment of cortical activation during gait-related imaginary tasks,” Journal of Neural Transmission, Vol. 116, pp. 1087 – 1092, 2009 (IF=2.402, 125/243 in “Neuroscience”).

104.  H-L Liu, M-L Li, T-C Shih, S-M Huang, I-Y Lu, D-Y Lin, S-M Lin and K-C Ju, "Instantaneous Frequency Based Ultrasonic Temperature Estimation during Focused Ultrasound Thermal Therapy," Ultrasound in Medicine and Biology, Vol. 35, No. 10, pp. 1647-1661, 2009 (IF=2.214, 5/29 in“Acoustics”).

105.  K-J Lin**, H-L Liu**, P-H Hsu, Y-H Chung,W-C Huang, J-C Chen, S-P Wey, T-C Yen, I-T Hsiao, “Quantitative microSPECT/CT for detecting focused ultrasound induced blood-brain barrier opening in the rat,” Nuclear Medicine and Biology, Vol. 36, No. 7, pp. 853-867, 2009 (**共同第一作者, IF=2.412, 42/125 in “Radiology”).

106.    H-L Liu and C-M Hsieh, "Single-Transducer Dual-Frequency Ultrasound Generation to Enhance Acoustic Cavitation," Ultrasononics Sonochemistry, Vol. 16, No. 3, pp. 431-438, 2009 (IF=6.012, 1/31 in “Acoustics”).

107.  H-L Liu, P-H Hsu, P-J Ju, Y-Y Wai, J-C Chen, C-R Shen, T-C Yen, and J-J Wang, "Magnetic Resonance Imaging Enhanced by Superparamagnetic Iron Oxide Particles: Usefulness for Distinguishing Between Focused Ultrasound-Induced Blood-Brain Barrier Disruption and Brain Hemorrhage," Journal of Magnetic Resonance Imaging, Vol. 29, No. 1, pp. 31-38, 2009(IF=3.210, 23/125 in “Radiology”).

108.   H-L Liu, H-W Chen, Z-H Kuo, and W-C Huang, “Design and Experimental Evaluations of a Low-Frequency Hemispherical Ultrasound Phased-Array System for Transcranial Blood-Brain Barrier Disruption” IEEE Transactions on Biomedical Engineering, Vol.55, No. 10, pp. 2407-2416., 2008 (IF=4.288, 9/78 in “Engineering, Biomedical”).

109.  J-J Wang, Y-C Lin, Y-Y Wai, H-L Liu, C-P Lin, Y-Z Huang, “Visualization of the coherence of the principal diffusion orientation: an eigenvector-based approach,” Magnetic Resonance in Medicine, Vol. 59, No. 4, pp.764-770, 2008 (IF=3.267, 22/120 in “Radiology”).

110    H-L Liu, Y-Y Wai, W-S Chen, J-C Chen, P-H Hsu, X-Y W, W-C Huang, T-C Yen, and J-J Wang, “Hemorrhage Detection during Focused-Ultrasound Induced Blood–Brain-Barrier Opening by Using Susceptibility-Weighted Magnetic Resonance Imaging,” Ultrasound in Medicine & Biology, Vol. 34, No. 4, pp. 598-606, 2008 (IF=2.645, 7/32 in “Acoustics”).

111.   T-C Shih, H-L Liu, K-C Ju, C-S Huang, P-Y Chen, H-W Huang, Y-J Ho, “The feasibility of heating on tumor periphery by using high intensity focused ultrasound thermal surgery,” Int. Comm. Heat Mass Trans., Vol. 35, pp. 439-445, 2008 (IF=2.315, 8/54 in “Thermodynamics”).

112.  H-L Liu, H Chang, W-S Chen, T-C Shih, J-K Hsiao, and W-L Lin, “Feasibility of Transrib Focused Ultrasound Thermal Ablation for Liver Tumors Using a Spherically Curved 2D Array: A Numerical Study,” Medical Physics, Vol. 34, No. 9, pp. 3436-3448, 2007 (IF=2.884, 36/126 in “Radiology”).

113.   H-L Liu , T-C Shih , W-S Chen and K-C Ju,“A Novel Strategy to Increase Heating Efficiency in a Split-Focus Ultrasound Phased Array,” Medical Physics, Vol. 34, No. 7, pp. 2957-2967, 2007 (IF=2.884, 36/126 in “Radiology”).

114.  H-L Liu, W-L Lin, and Y-Y Chen , “A Fast and Conformal Heating Scheme for Producing Large Thermal Lesions Using a 2-D Ultrasound Phased Array,” International Journal of Hyperthermia, Vol. 23, No. 1, pp. 69 – 82, 2007 (IF=2.645, 37/125in “Radiology”).

115.  H-L Liu, Y-Y Chen, W-S Chen, T-C Shih, J-S Chen, and W-L Lin, "Interactions between consecutive sonications for characterizing the thermal mechanism in focused ultrasound therapy,” Ultrasound in Medicine & Biology, Vol. 32, No. 9, pp. 1411 – 1421, 2006 (IF=2.645, 7/32 in “Acoustics”).

116.  Y-S Tung, H-L Liu, C-C Wu, K-C Ju, W-S Chen, and W-L Lin, “Contrast-agent enhanced ultrasound thermal ablation,” Ultrasound in Medicine & Biology, Vol. 32, No. 7, pp. 1103 – 1110, 2006 (IF=2.645, 7/32 in “Acoustics”).

117.   W-S Chen, C-C Wu, S-Y Fang, H-L Liu* (Corresponding author), “Differences in the lesion formation process between focused ultrasound and microwave ablations,” Medical Physics, Vol. 33, No. 5, pp. 1346-1351, 2006 (IF=2.884, 36/126 in “Radiology”).

118.  H-L Liu, W-S Chen, J-S Chen, T-C Shih, Y-Y Chen, and W-L Lin, "Cavitation - Enhanced Ultrasound Thermal Therapy by Combined Low- and High-Frequency Ultrasound Exposure,” Ultrasound in Medicine & Biology, Vol. 32, No. 5, pp. 759-767, 2006 (SCI IF:2.021, 4/31 in“Acoustics”).

119.  T-C Shih, H-L Liu, and Allen T-L Horng, “Cooling effect of thermally significant blood vessels in perfused tumor tissue during thermal therapy,” Int. Comm. Heat Mass Trans., Vol. 33, pp. 135-141, 2006 (IF=2.315, 8/54 in “Thermodynamics”).

120.  W-S Chen, P-M Ma, H-L Liu, C-K Yeh, M-S Chen, and C-W Chang, "A novel method for estimating the focal size of two confocal high-intensity focused ultrasound transducers," J. Acoust. Soc. Am., Vol. 117, No. 6, pp.3740-3749, 2005 (IF=1.646, 9/31 in “Acoustics”).

121.  H-L Liu, Nathan McDannold, and K. Hynynen, “Focal beam distortion and treatment planning in abdominal focused ultrasound surgery,” Medical Physics, Vol. 32, pp.1270-1280, 2005 (IF=2.884, 36/126 in “Radiology”).

122.  H-L Liu, Y-Y Chen, J-Y Yen and W-L Lin, “A Pilot Point Temperature Regulation for Thermal Dose Control during Ultrasound Thermal Therapy,” Medical & Biological Engineering & Computing, Vol. 42, pp. 178-188, 2004 (IF=1.791, 33/79 in “Engineering, Biomedical”).

123.  H-L Liu, Y-Y Chen, J-Y Yen, W-L Lin, “Thermal lesion formation and determination in external ultrasound thermal therapy,” Biomedical Engineering – Applications, Basis, and Communications, Vol. 15, No. 3, pp. 124-132, 2003 (EI ).

124.  H-L Liu, Y-Y Chen, J-Y Yen and W-L Lin, “Treatment time reduction for large thermal lesions by using a multiple 1-d ultrasound phased array system,” Physics in Medicine and Biology, Vol. 48, pp.1173-1190, 2003 (IF=2.701, 19/79 in “Engineering, Biomedical”).

125.  W-L Lin, T-C Liang, J-Y Yen, H-L Liu and Y-Y Chen, “Optimization of power deposition and a heating strategy for ultrasound thermal therapy,” Medical Physics, Vol. 28, No. 10, pp. 2172-2181, 2001 (IF=2.884, 36/126 in “Radiology”).

126.  Y-Y Chen, W-L Lin, H-L Liu, J-Y Yen and M-J Shieh, “Self-tuning fuzzy logic control for ultrasound hyperthermia with reference temperature based on objective functions,” Medical Physics, Vol. 26, No. 5, pp. 825-833, 1999 (IF=2.884, 36/126 in “Radiology”).

 (B) Patents

l  H-L Liu, S-F Chen, and H Chang, "Multiple-Frequency Ultrasonic Phased Array Driving System, " EU Patent No. EP2640465, Nov. 7, 2018.

l  H-L Liu, K-C Wei, H-C Tsai, L-Y Lu, " Neuronavigation-guided focused ultrasound system and method thereof," EU Patent No. EP2858619A4, 2018. 

l  H-L Liu, K-C Wei, H-C Tsai, L-Y Lu, " Neuronavigation-guided focused ultrasound system and method thereof," CA Patent No. CN103479403B, 2016.

l  HL Liu, KC Wei, PY Chen, PH Hsu, PC Chu, WY Chai, CY Lin, Method for ultrasound mediated delivery system to monitor molecular penetration, US Patent, 10076652B2, Sept. 18, 2017.

l  HL Liu, MT Tsai, CK Yeh, Imaging devices, systems, and methods of operation for acoustic-enhanced optical coherence tomography, US Patent 15702574, 2018.

l  劉浩澧、蔡宏杰、盧郁仁、魏國珍，“以手術導航系統導引聚焦式超音波釋放能量之系統及其方法，”澳洲, 2013271506, 2017.

l  劉浩澧、蔡孟燦、葉秩光，聲致顯影增強光同調影像之鏡頭及其系統和運作方法，中華民國(發明),I616690, 2018.

l  劉浩澧、蔡宏杰、盧郁仁、魏國珍，“手術ナビゲーションシステムを用いた集束超音波放出エネルギーの誘導システムとその方法，”日本 (發明),  特許第6188036, July 22, 2017.

l  HL Liu, CH Tsai, KC Wei, PY Chen, “Processing system and processing method for confocally emitting and receiving ultrasound,” U.S. Patent, US9743908B2, 2017.

l  HL Liu and MS Lin, “High-intensity focused ultrasound thermal therapy ablation apparatus having integrated temperature estimation and elastography for thermal lesion determination and the method thereof,” U.S. Patent, US 9,643,030B2 May 9, 2017.

l  劉浩澧、張恕、陳聖夫，“複頻超音波相位陣列驅動系統”，中華人民共和國(發明), CN103347564B, Sept. 21, 2016.

l  劉浩澧、蔡宏杰、盧郁仁、魏國珍，“以手術導航系統導引聚焦式超音波釋放能量之系統及其方法，”中華人民共和國(發明), CN103479403B, June 22, 2016.

l  H-L Liu, S-F Chen, and H Chang, “超音波処理装置及び超音波処理方法,” Japan, 特許第5740004號, May 1, 2015.

l  M-L Li, H-L Liu, D-W Li, "Method for dynamically analyzing distribution variation of scatterers and application using the same,” U.S. Patent No. 2,913,481, June 9, 2015.

l  M-Y Hua, H-W Yang, C-K Chuang, S-T Pang, H-L Liu, R-Y Tsai, K-L Chuang, "Magnetic Nanomedicine for Inhibiting/Targeting Human Prostate Cancer," U. S. Patent , U.S. Patent No. 8,889,192, Nov. 18, 2014.

l  H-L Liu, S-F Chen, and H Chang, "Multiple-Frequency Ultrasonic Phased Array Driving System, " U. S. Patent No. 8485974, July 16, 2013.

l  H-L Liu, C-C Kung, T-C Chang, “Schlieren type ultrasonic wave observer system,” U. S. Patent, U.S. Patent No. 8,462,326, June 11, 2013.

l  H-L Liu, W-L Lin, and H Chang, “Medical Treatment using an Ultrasound Phased Array,” U. S. Patent No. 8,287471, Oct 16, 2012.

l  H-L Liu, C-H Kuo, and H-W Chen, “Biomedical Used Multiple-Channel Hemispherical Focused Ultrasound Phased Array Apparatus, U. S. Patent No.8,226,538, July 24, 2012.

l  H-L Liu, I-Y Lu and S-M Huang, "Method and apparatus for real-time temperature measuring for high-intensity focused ultrasound (HIFU) therapy system," U. S. Patent No. 8,226,559, July 24, 2012.

l  H-L Liu, W-S Chen, and C-K Jan, “Precision Method and Apparatus for Controlling the Shape Memory Alloy,” U.S. Patent US8046994, Nov. 01, 2011.

l  W-S Chen, H-L Liu, Y-T Huang, C-C Ma, W-B Tsai, W-P Shih, C-A Dai, “Artificial sphincter system,” US Patent No. 795389, June 7, 2011, 2011.

l  H-L Liu and Chao-Ming Hsieh, “Multiple frequency driven ultrasound device,” US Patent No. 7,530,272, May. 12, 2009.

l  劉浩澧、徐義涵、崔博翔、詹程凱,“超音波分析裝置,”中華民國(發明),I578693, 2017.

l  劉浩澧、魏國珍、陳品元、許博泓、朱伯駿、柴雯燕、林中英, “以超音波作為傳遞媒介之監控分子通透量的方法,” 中華民國(發明) , 專利號I562801, Dec. 12, 2016.

l  劉浩澧、蔡至洪、魏國珍、陳品元, “超音波收發處理系統及其處理方法,” 中華民國(發明) , I552730, 10/16, 2016.

l  劉浩澧、詹程凱, 口袋型超音波溫度分析儀及其量測方法，中華民國(發明), I514991, 01/01, 2016.

l  馬蘊華, 劉浩澧, 吳禹利, 劉少凱, 標靶藥物之投藥系統及其操作方法，中華民國(發明), I491425 , 07/11, 2015

l  劉浩澧、蔡宏杰、盧郁仁、魏國珍、陳品元，以手術導航系統導引聚焦式超音波釋放能量之系統及其方法，中華民國(發明), I488613, 06/21, 2015

l  劉浩澧，林俊安，超音波即時功率監控系統，中華民國(發明), 專利號I489802, June 21, 2015.

l  華沐怡、劉浩澧、楊閎蔚、魏國珍、陳品元、蔡榮源，具有多重反應性官能基之磁性奈米粒子複合物及其製備方法，中華民國(發明), I445550, 7/21，2014.

l  劉浩澧、林明熙，一種具有超音波溫度影像及彈性影像之高能聚焦式超音波裝置及其使用方法，專利號I444210, July 11, 2014.

l  劉浩澧、陳聖夫、張恕，複頻超音波相位陣列驅動系統, 中華民國(發明), 專利號I426245, Feb. 11, 2014.

l  劉浩澧、龔崇誠、張庭嘉，一種光學式超音波觀測裝置及其延遲同步控制的方法，中華民國(發明), 專利號I409452, Sept. 21, 2013.

l  劉浩澧、盧奕曄、黃聖閔, 非侵入式超音波即時溫度量測裝置及其方法, 中華民國(發明), 專利號I406684, Sept. 1, 2013, 2013.

l  劉浩澧、黃文正, 非侵入式低頻超音波腦部治療裝置, 中華民國(發明), 申請號, 專利號I382860, Jan. 21, 2013.

l  劉浩澧、林文澧、張恕, “一種以超音波相位陣列達到穿透肋骨治療之系統及方法, 中華民國(發明),” 專利號I377076, Nov. 21, 2012.

l  劉浩澧、陳文翔、詹程凱,"一種形狀記憶合金的控制器裝置和控制方法,” 中華民國(發明), 專利號I367410, July 1, 2012.

l  陳文翔、劉浩澧、黃彥棟、馬劍清、蔡偉博、施文彬、戴子安，“人工括約肌系統,” 中華民國(發明), 專利號I351271, Nov. 11, 2011.

l  劉浩澧、謝兆鳴, “多頻驅動單一換能器之超音波系統及訊號產生裝置”, 中華民國(發明), 專利號I323196, April 11, 2010.

l  劉浩澧、郭鎮豪、陳恆文，“生物醫療用半圓頭罩式超音波相位陣列裝置,” 中華民國(發明), 專利號I337087, Feb. 11, 2011.