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Department of Electrical Engineering

Hsiao-Lung Chan





LAB: Biomedical Electronics and Signals Lab ( Phone 5716 )

Contact information:



Research fields:

Biomedical informatics, medical electronics, digital signal processing, embeded system

More information here:


Publication List

A. 期刊論文 (* denoting corresponding author)

1. H.L. Chan*, J.H. Chu, H.C. Fung, Y.T. Tsai, L.F. Meng, C.C. Huang, W.C. Hsu, P.K. Chao, J.J. Wang, J.D. Lee, Y.Y. Wai, M.T. Tsai, “Brain connectivity of patients with Alzheimer’s disease by coherence and cross mutual information of electroencephalograms during photic stimulation,” Medical Engineering & Physics doi:10.1016/j.medengphy.2011.10.005 (SCI/EI) (impact factor 1.906).

2. P.K. Chao, C.L. Wang, H.L. Chan*, “An intelligent classifier for prognosis of cardiac resynchronization therapy based on speckle-tracking echocardiograms,” Artificial Intelligence in Medicine doi:10.1016/j.artmed.2011.09.006 (SCI) (impact factor 1.568) (* corresponding author).

3. P.K. Chao, C.L. Wang, H.L. Chan*, “Phase space analysis on myocardial coordination related to left ventricular ejection fraction by speckle-tracking radial strain,” Medical Engineering & Physics 10.1016/j.medengphy.2011.07.003 (SCI/EI) (impact factor 1.906) (* corresponding author).

4. P.K. Chao, H.L. Chan*, J.J. Huang, W.Y. Hsu, “Heart rate variability estimated by heart instantaneous frequency in low-constrained task,” International Journal of Medical Imaging and Health Informatics. vol. 1, pp.353-350, 2011. (EI) (* corresponding author).

5. H.L. Chan*, Y.C. Chiu, Y.A. Kao, C.L. Wang, “VLSI implementation of wavelet-based electrocardiogram compression and decompression,” Journal of Medical and Biological Engineering, vol.31, no.5, pp.331-338, 2011. (SCI) (impact factor 0.42) (NSC97-2220-E-182-001).

6. C.C. Chen, W.Y. Lin, H.L. Chan, Y.T. Hsu, P.H. Tu, S.T. Lee, S.M. Chiou, C.H. Tsai, C.S. Lu, P. Brown, “Stimulation of the subthalamic region at 20 Hz slows the development of grip force in Parkinson’s disease,” Experimental Neurology, vol. 231, pp.91-96, 2011. (SCI) (impact factor 4.436).

7. P.K. Chao, H.L. Chan*, C.L. Wang, L.S. Wu, “Patterns of left ventricular contraction in strain vector space related to bundle branch block with heart failure by speckle-tracking echocardiography,” Ultrasound in Medicine and Biology, vol. 37, pp.595-604, 2011 (SCI) (impact factor 2.493)  (* corresponding author) (NSC96-2314-B-182A-137)

8. H.L. Chan*, Y.T. Tsai, L.F. Meng, T. Wu, “The removal of ocular artifacts from EEG signals using adaptive filters based on ocular source components,” Annals of Biomedical Engineering, vol. 38, pp.3489-3499, 2010. (SCI) (impact factor 2.374) (NSC 96-2221-E-182-001- MY3)

9. Y.T. Tsai, H.L. Chan, S.T. Lee, P.H. Tu, B.L. Chang, T. Wu, “Significant thalamocortical coherence of sleep spindle, theta, delta, and slow oscillations in NREM sleep: recordings from the human thalamus,” Neuroscience Letters, vol. 485, pp.173-177, 2010. (SCI) (impact factor 2.055).

10. C.C. Chen, Y.T. Hsu, H.L. Chan, S.M. Chiou, P.H. Tu, S.T. Lee, C.H. Tsai, C.S. Lu, P. Brown, “Complexity of subthalamic 13-35 Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson’s disease,” Experimental Neurology, vol. 224, pp.234-240, 2010. (SCI) (impact factor 4.436).

11. H.L. Chan*, C.L. Wang, S.C. Fang, P.K. Chao, C.D. Wei, “Recognition of ventricular extrasystoles over the reconstructed phase space of electrocardiogram,” Annals of Biomedical Engineering, vol. 38, pp.813-823, 2010. (SCI) (impact factor 2.374) (NSC97-2220-E-182-001)

12. H.L. Chan*, T. Wu, S.T. Lee, M.A. Lin, S.M. He, P.K. Chao, Y.T. Tsai, “Unsupervised wavelet-based spike sorting with dynamic codebook searching and replenishment,” Neurocomputing, vol. 73, pp. 1513-1527, 2010. (SCI) (impact factor 1.429)

13. H.L. Chan, M.A. Lin, S.T. Lee, Y.T. Tsai, P.K. Chao, T. Wu, “Complex analysis of neuronal spike trains of deep brain nuclei in Parkinson patients,” Brain Research Bulletin, vol. 81, pp. 534-542, 2010 (SCI) (impact factor 2.498).

14. P.K. Chao, H.L. Chan*, F.T. Tang, Y.C. Chen, M.K. Wong, “A comparison of automatic fall detection by cross-product and magnitude of tri-axial acceleration,” Physiological Measurement, vol. 30, pp. 1027-1037, 2009. (SCI) (impact factor 1.567) (NSC97-2220-E-182-001) (* corresponding author).

15. S.C. Fang, H.L. Chan*, “Human identification by quantifying similarity and dissimilarity in electrocardiogram phase space,” Pattern Recognition, vol. 42, pp. 1824-1831, 2009. (SCI) (impact factor 2.607) (* corresponding author).

16. P.K. Chao, H.L. Chan*, T. Wu, M.A. Lin, S.T. Lee, “Classifying deep brain neuronal activities by bursting parameters,” International Journal of Innovative Computing, Information and Control, vol. 5, no. 4, pp. 847-854, 2009. (SCI) (impact factor 1.664) (* corresponding author).

17. H.H. Huang, Y.H. Lee, H.L. Chan, Y.P. Wang, C.H. Huang, S.Z. Fan, “Using a short-term parameter of heart rate variability to distinguish awake from isoflurane anesthetic states,” Medical and Biological Engineering and Computing, vol. 46, pp. 977-984, 2008. (SCI) (impact factor 1.791)

18. H.L. Chan*, M.A. Lin, T. Wu, S.T. Lee, Y.T. Tsai, P.K. Chao, “Detection of neuronal spikes using an adaptive threshold based on the max-min spread sorting method,” Journal of Neuroscience Methods, vol. 172, pp. 112-121, 2008. (SCI) (impact factor 2.100)

19. H.L. Chan*, Y.C. Siao, S.W. Chen, S.F. Yu, “Wavelet-based ECG compression by the bit-field preserving and running length encoding,” Computer Methods and Programs in Biomedicine, vol. 90, pp. 1-8, 2008. (SCI) (impact factor 1.238) (NSC95-2221- E-182-064).

20. H.L. Chan*, T. Wu, S.T. Lee, S.C. Fang, P.K. Chao, M.A. Lin, “Classification of neuronal spikes over the reconstructed phase space,” Journal of Neuroscience Methods, vol. 168, pp. 203-211, 2008. (SCI) (impact factor 2.100)

21. L.F. Meng, C.P. Lu, H.L. Chan, “Time-varying brain potentials and interhemispheric coherences of anterior and posterior regions during repetitive unimanual finger movements,” Sensors, vol. 7, pp. 960-978, 2007. (SCI) (impact factor 1.771)

22. H.L. Chan*, M.A. Lin, P.K. Chao, C.H. Lin, “Correlates of the shift in heart rate variability with postures and walking by time-frequency analysis,” Computer Methods and Programs in Biomedicine, vol. 86, pp.124-130, 2007. (SCI) (impact factor 1.238) (NSC90-2213- E-182-006).

23. K.M. Chiu, H.L. Chan, S.H. Chu, T.Y. Lin, “Carvedilol can restore the multifractal properties of heart beat dynamics in patients with advanced congestive heart failure,” Autonomic Neuroscience: Basic and Clinical , vol.132, pp.76-80, 2007. (SCI) (impact factor 1.671)

24. H.L. Chan*, L.Y. Lin, M.A. Lin, S.C. Fang, C.H. Lin, “Nonlinear characteristics of heart rate variability during unsupervised and steady physical activities,” Physiological Measurement, vol.28, pp.277-286, 2007. (SCI) (impact factor 1.567) (NSC94-2614-E-182-004)

25. S.M. Tseng, M.C. Chang, H.L. Chan, Y.T. Hsu, “A simplified decoding scheme of an optical transform domain error control code,” Journal of Optical Communications, vol.27, pp.238-240, 2006. (EI)

26. S.M. Tseng, Y.T. Hsu, M.C. Chang, H.L. Chan, “A notebook PC based real-time software radio DAB receiver,” IEICE Transactions on Communications, vol.E89-B, no.12, pp.3208-3214, 2006. (SCI) (impact factor 0.301)

27. S.W. Chen, H.C. Chen, H.L. Chan, “A moving-average based system incorporating wavelet denoising for real-time QRS detection,” Computer Methods and Programs in Biomedicine, vol.82, pp.187-195, 2006. (SCI) (impact factor 1.238)

28. H.L. Chan*, S.C. Fang, Y.L. Ko, M.A. Lin, H.H. Huang, C.H. Lin, “Heart rate variability characterization in daily physical activity using wavelet analysis and multi-layer fuzzy activity clustering, IEEE Transactions on Biomedical Engineering, vol.53, no.1, pp.133-139, 2006. (SCI) (impact factor 1.782)(NSC90-2213- E-182-006)

29. H.L. Chan*, W.S. Chou, S.W. Chen, S.C. Fang, C.S. Liou, Y.S. Hwang, “Continuous and on-line analysis of heart rate variability,” Journal of Medical Engineering & Technology, vol.29 no.5, pp.227-234, 2005. (EI) (NSC89-2626-E-146-003)

30. L.Y. Lin, J.J. Hwang, L.P. Lai, H.L. Chan, C.C. Du, Y.Z. Tseng, J.L, Lin, “Restoration of heart rate turbulence by titrated beta-blocker therapy in patients with advanced congestive heart failure: positive correlation with enhanced vagal modulation of heart rate,” Journal of Cardiovascular Electrophysiology, vol.15, no.7, pp.752-756, 2004. (SCI) (impact factor 3.288)

31. M.S. Tsai, Y.T. Wu, H.L. ChanJ.S. Lai, T.Y. Tai, “Influencing factors of resting heart rate variability in diabetes mellitus,” Formosan Journal of Medicine, vol.7, no.1, pp.10–19, 2003.

32. L.Y Lin, L.P Lai, J.L. Lin, C.C. Du, W.Y. Shau, H.L. Chan, Y.Z Tseng, S.K. Huang, “Tight mechanism correlation between heart rate turbulence and baroreflex sensitivity: sequential autonomic blockade analysis,” Journal of Cardiovascular Electrophysiology, vol.13, no.5, pp.427 – 431, 2002. (SCI) (impact factor 3.288)

33. H.L. Chan*, H.H. Huang, J.L. Lin, “Time-frequency analysis of heart rate variability during transient segment,” Annals of Biomedical Engineering, vol.29, iss.11, pp. 983-996, 2001. (SCI) (impact factor 2.374) (NSC89-2626-E-146-003)

34. P.L. Lin, Y.P. Wang, Y.M. Chou, H.L. Chan, H.H. Huang, "Lack of intravenous lidocaine effects on HRV changes of tracheal intubation during induction of general anesthesia," Acta Anesthesiologica Sinica, vol.39, pp.77-82, 2001.

35. Y.H. Wang, T.S. Hwang, J.L. Lin, J.J. Huang, H.L. Chan, J.S. Lai, Y.Z. Tseng, “Decreased autonomic nervous system activity as assessed by heart rate variability in chronic cervical spinal cord injuried patients as compared with lumbar spinal cord injuried patients,” Archives of Physical Medicine and Rehabilitation, pp.1181-1184, 2000. (SCI) (impact factor 2.254)

36. D.C. Chiou, H.H. Huang, H.L. Chan, C.P. Wu, ”Extraction of 1/f component from heart beat interval signal by singular spectral analysis,” IEICE Transactions on Information and Systems, vol.E83-D, pp.302-304, 2000. (SCI) (impact factor 0.265)

37. J.L. Lin, H.L. Chan, I.N. Lin, C.C. Du, C.W. Lai, K.T. Lin, C.P. Wu, Y.Z. Tseng, W.P. Lien, “Long-term b-blocker therapy improves autonomic nervous regulation in advanced congestive heart failure - a longitudinal heart rate variability study,“ American Heart Journal, vol.137, no.4, pp.658-665, 1999. (SCI) (impact factor 5.052)

38. C.D. Tsai, D.C. Chiou, Y.D. Lin, H.L. Chan, C.P. Wu, “An active comb filter design for harmonic interference removal,” Journal of the Chinese Institute of Engineers, vol.21, no.5, pp.605-610, 1998. (SCI) (impact factor 0.225)

39. H.H. Huang, H.L. Chan, P.L. Lin, C.P. Wu, C.H. Huang, “Time-frequency analysis of heart rate variability during induction of general anaesthesia,” British Journal of Anaesthesia, vol.79, pp.754-758, 1997. (SCI) (impact factor 4.224)

40. H.L. Chan, J.L. Lin, H.H. Huang. C.P. Wu, “Elimination of interference component in Wigner-Ville distribution for the signal with 1/f spectral characteristic,” IEEE Transactions on Biomedical Engineering, vol.44, no.9, pp.903-907, 1997. (SCI)(impact factor 1.782)

41. H.L. Chan, J.L. Lin, C.C. Du, C.P. Wu, “Time-frequency distribution of heart rate variability below 0.05 Hz by Wigner-Ville spectral analysis in congestive heart failure patients,” Medical Engineering & Physics, vol.19, no.6, pp.581-587, 1997. (SCI) (impact factor 1.906)

42. C.D. Tsai, H.H. Huang, S.L.Tsao, H.L. Chan, C.P. Wu, “Error reduction of referenced intensity-based optical fibre sensor by adaptive noise canceller,” IEE Electronics Letters, vol.33, no.11, pp.982-983, 1997. (SCI) (impact factor 1.001)

43. H.L. Chan, H.H. Huang, C.P. Wu, J.L. Lin, “A new approach for time-frequency analysis of heart rate variability and assessment of time-frequency representations,” Journal of the Chinese Institute of Engineers, vol.20, no.3, pp.343-353, 1997. (SCI) (impact factor 0.225)

44. H.L. Chan, C.D. Tsai, H.H. Huang, D.C. Chiou, C.P. Wu, “Photodetector with filter,” IEE Electronics Letters, vol.33, no.2, pp.163-164, 1997. (SCI) (impact factor 1.001) (NSC86-2213-E-002-003)

45. H.L. Chan, J.L. Lin, C.C. Du, I.N. Lin, K.T. Lin, C.P. Wu, W.P. Lien, “The high-resolution time-frequency characteristics of slower frequency heart rate variability in patients of chronic refractory congestive heart failure- the implications of beta-blocker therapy,” Biomedical Engineering- Applications, Basis, Communications, vol.8, no.5, pp.447-461, 1996. (SCI) (impact factor 0.188)

46. I.N. Lin, C.W. Lai, J.L. Lin, H.L. Chan, K.T. Lin, C.P. Wu, W.P. Lien, “Simultaneous improvement of cardiac contractile performance and autonomic nervous regulation by chronic atenolol-added treatment in advanced congestive heart failure- a combined echocardiography and heart rate variability study,” Acta Cardiologica Sinica, vol.12, no.4, 1996.


B. 研討會論文

1. H.L. Chan, Y.T. Tsai, B.L. Chang, T. Wu, S.T. Lee, B.S. Lin, P.K. Chao, “Detection of intracranial electroencephalogram spikes by phase space reconstruction.” 5th European IFMBE Conference, Budapest, Hungary, IFMBE Proceedings 37, pp. 150–153, 2011.

2. P.K. Chao, M.H. Yao, H.L. Chan, C.L. Wang, “Detecting endocardial boundary in echocardiogram by anisotropic filtering and entropy-weighted features.” 5th European IFMBE ConferenceBudapest, Hungary, IFMBE Proceedings 37, pp. 607–610, 2011.

3. H.L. Chan, Y.T. Tsai, C.C. Huang, W.C. Hsu, J.H. Chu, L.F. Meng, P.K. Chao, “Brain connectivity of patients with Alzheimer’s disease by coherence analysis of electroencephalograms.” Proceedings of the First International Symposium on Bioengineering, Singapore, pp.104–110, 2011.

4. P.K. Chao, J.J. Huamg, H.L. Chan, “Heart instantaneous frequency based on electrocardiograms recorded by portable sensors during outdoor jogging,“ Proceedings of the First International Symposium on Bioengineering, Singapore, pp. 161-169, 2011.

5.Y.T. Tsai, H.L. Chan, S.T. Lee, P.H. Tu, B.L. Chang, T. Wu, “Sleep spindle oscillation regulated unilaterally: recording from human thalamus,” 29th International Congress of Clinical Neurophysiology, Kobe, Japan, 2010.

6. H.L. Chan, L.F. Meng, W.C. Hsu, Y-T. Tsai, C.Z. Yu, C.P. Lu, H.C. Feng, Y.C. Chu, “Effect of gesture-tool incongruence on cognitive potentials in patients with mild cognitive impairment,” 14th Congress of the European Federation of Neurological Societies, Geneva, Switzerland, 2010.

7. H.L. Chan, S.C. Fang, P.K. Chao, C.L. Wang, J.D. Wei, “Phase-space reconstruction of electrocardiogram for heartbeat classification,” IFMBE Proceedings 25/IV, pp. 1234–1237, The World Congress on Medical Physics and Biomedical Engineering, Munich, Germany, 2009. (EI)

8. P.K. Chao, H.L. Chan, C.L. Wang, “An intelligent classifier for heart health– based on radial myocardial strain and electrocardiogram,” IFMBE Proceedings 25/IV, pp. 1337–1340, The World Congress on Medical Physics and Biomedical Engineering, Munich, Germany, 2009. (EI)

9. C.Z. Yu, L.F. Meng, H.L. Chan, Y.T. Tsai, W.C. Hsu, Y.Y. Lu, C.P. Lu, P.Y. Wu, “Effects of gesture-tool congruence on event-related congruent potential,” Annual Symposium of the Biomedical Engineering Society ROC, Taipei, 2009.

10. H.L. Chan, M.A. Lin, T. Wu, P.K. Chao, S.T. Lee, P.C. Chen, “Analysis of microelectrographic neuronal background in deep brain nuclei in Parkinson disease,” Lecture Notes in Computer Science, vol. 5506, pp. 194-199, The 15th International Conference on Neural Information Processing, Auckland, New Zealand, 2008. (EI)

11. HL. Chan, P.K. Chao, YC. Chen, WJ. Kao, “Wireless body area network for physical activity classification and fall detection,” The 5th International Workshop on Wearable and Implantable Body Sensor Networks, (BSN 2008), in conjunction with the 5th International Summer School and Symposium on Medical Devices and Biosensors (ISSS-MDBS 2008), Hong Kong, June, 2008. (EI)

12. P.K. Chao, H.L. Chan, T. Wu, M.A. Lin, S.T. Lee, “Applying the string method to extract bursting information from microelectrode recordings in subthalamic nucleus and subtantia nigra,” Lecture Notes in Computer Science, vol. 4984, pp. 48-53, The 14th International Conference on Neural Information Processing, Kitakyushu, Japan, 2007. (EI) 

13. H.L. Chan, L.F. Meng, P.K. Chao, M.A. Lin, "Coherence analyses of event-related potentials using Fourier and wavelet transforms," The 3rd International IEEE EMBS Conference on Neural Engineering, pp.627-629, Hawaii, USA, May, 2007. (EI)

14. P.K. Chao, H.L. Chan, M.A. Lin, Y.L. Wu, S.T. Lee, "Quantifying the features of deep brain signals by expectation-maximization algorithm," Annual Symposium of the Biomedical Engineering Society ROC, Taipei, December, 2006.

15. H.L. Chan, C.Y. Lu, C.H. Liu, M.A. Lin, “Low-power wireless transmission using the slotted ALOHA mechanism,” IEEE Conference on Systems, Man, and Cybernetics, pp.513-517, Taipei, Taiwan, October, 2006. (EI)

16. H.L. Chan, M.A. Lin, Y.L. Wu, H.Y. Lai, S.T. Lee, G.F. Yang, S.C. Fang, “Detection and characterization of neural spikes,” The 3rd Advances in Medical, Signal and Information Processing, Glasgow, United Kindom, July, 2006.

17. H.L. Chan, G.U. Chen, M.A. Lin, S.C. Fang, “Heartbeat detection using energy thresholding and template match, Proceedings of 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Shanghai, China, 2005. (EI)

18. M.A. Lin, H.L. Chan, S.C. Fang, ”Linear and nonlinear EEG indexes in relation to the severity of coma,” Proceedings of 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Shanghai, China, 2005. (EI).

19. S.C. Fang, H.L. Chan, S.C. Chen, ”Combination of linear and nonlinear methods on electroencephalogram state recognition,” Proceedings of 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Shanghai, China, 2005. (EI).

20. M.C. Chang, C.W. Chang, C.H. Hsia and H.L. Chan, “Design of an electrocardiogram QRS complex detector employing Tompkins method and template matching,” Proceedings of the 2005 Workshop on Consumer Electronics and Signal Processing (WCESP), 2005.

21. H.L. Chan, M.H. Yeh, M.A. Lin, “An ALOHA-based wireless transmission of physiological signals,” IEEE International Conference on Mechatronics, Taipei, Taiwan, 2005.

22. H.L. Chan, M.A. Lin, S.C. Fang, “Linear and nonlinear analysis of electroencephalogram of the coma, Proceedings of 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp.593-595, San Francisco, USA, 2004. (EI)

23. S.C. Fang, H.L. Chan, W.H Chen, “Approximate entropy analysis of electroencephalogram in vasovagal syncope on tilt table test,” Proceedings of 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp.590-592, San Francisco, USA, 2004. (EI)

24. M.A. Lin, H.L. Chan, S.C. Fang, “Classification of the come brain wave and the normal brain wave,” Annual Symposium of the Biomedical Engineering Society ROC, 2004.

25. M.C. Chang, Z.X. Lin, C.W.. Chang, H.L. Chan, and W.S. Feng, “Design of a system-on-chip for ECG signal processing,” IEEE Asia-Pacific Conference on Circuit and Systems, pp. 441-444, December, 2004.

26. M.C. Chang, Z.X. Lin, C.W. Chang, R.Y. Tsai, H.L. Chan, and W.S. Feng, “Design of an ARM-based system-on-chip for real-time QRS detection in electrocardiograms,” International Conference on Informatics, Cybernetics, and Systems, pp.319-324, December, 2003.

27. W.Y. Lin, H.L. Chan, S.C. Fang, J.D. Lee, Y.H. Lee, “Complex analysis of gene sequence,” Applied Engineering and Technology Symposium of Formosa Plastics Group, 2003.

28. H.L. Chan, C.H. Lin, Y.L. Ko, “Segmentation of heart rate variability in different physical activities,” Computers in Cardiology, 30: 97-100, Thessaloniki, Greece, 2003. (EI)

29. H.L. Chan, C.S. Liou, W.S. Chou, Y.S. Huang, M.H. Hsu, “Design of DSP-Based Heart Rate Variability Analyzer,” IEEE/ASME International Conference, 2002.

30. H.L. Chan, C.S. Liou, W.S. Chou, Y.S. Huang, Y.Z. Chen, M.H. Hsu, “Time-varying analysis of heart rate variability based on DSP processor,” Annual Symposium of the Biomedical Engineering Society ROC, 2002.

31. H.L. Chan, M.H. Hsu, Y.L. Ko, C.S. Liou, ”Design of a portable physiological signal acquisition and transmission system,“ Applied Engineering and Technology Symposium of Formosa Plastics Group (AETSFPG 2001), TaoYuan, F-0007, 2001.

32. C.D. Tsai, S.L. Tsao, H.L. Chan, W.C. Shen, and C.P. Wu, “Microbending optical fiber sensor for the detection of low-level heart sound,” Pacific Rim Conference on Lasers and Electro-Optics, Chiba, Japan, p.312, 1997.

33. J.L. Lin, H.L. Chan, L.P. Lai, I.N. Lin, C.W. Lai, “Parallel improvement of cardiac performance and sympathovagal modulation in severe congestive heart failure by low-dose -blocker,” European Heart Journal, Vol.17 (Supplement), p10, 1996.

34. J.L. Lin, H.L. Chan, C.C. Du, W.P. Lin, “Time-frequency distribution study of lower frequency spectra of heart rate variability in severe congestive heart failure- low dose beta-blocker effect,” Journal of the American College of Cardiology, Vol.27, No.2 (Supplement A), p399A, 1996.

35. H.L. Chan, C.D. Tsai, S.L. Tsao, W.C. Shen, C.P. Wu, “Heart sound measurement by using microbending optical fiber sensor,” Optics Conference of Taiwan, pp. 138-139, 1996.

36. H.L. Chan, J.L. Lin, C.C. Du, C.P. Wu, “Lower frequency decomposition of 24-hour heart rate by Wigner-Ville spectral analysis,” 8th International Conference on Biomedical Engineering, pp.236-238, 1994.

37. H.L. Chan, J.L. Lin, C.C. Du, C.P. Wu, “Time-frequency analysis of 24-hour heart rate fluctuation for the characterization of very low-frequency component,” Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol.16, pp.1250-1251, 1994. (EI)

38. C.T. Tsai, H.L. Chan, C.C. Tseng, C.P. Wu, “Harmonic Interference Elimination by an active comb filter,” Proceedings of 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol.16, pp.964-965, 1994. (EI)

39. H.L. Chan, J.L. Lin, C.C. Du, C.P. Wu, “Spectrum segmentation of 24-hour heart rate variability,” The 1st IEEE/EMBS Region 10 International Conference, p111, 1994.

40. H.L. Chan, J.L. Lin, C.C. Du, C.P. Wu, “Spectral analysis of 24-hour heartbeat periods in heart failure,” Annual Symposium of the Biomedical Engineering Society ROC, pp.112-113, 1993.

41. Y.K. Huang, Y.M. Tseng, H.L. Chan, C.P. Wu, M. Ouhyoung, “A liver segmentation and 3D reconstruction system,” Annual Symposium of the Biomedical Engineering Society ROC, pp.66-71, 1992.



1. “Device and method for measuring three-lead ECG in a wristwatch”, USA Patent. CFP00873.

2. “Brain potential signal separation and method,” 中華民國發明專利 I309977.

3. “A second-order differential highpass filter,”中華民國發明第092084日本特許第3081565, USA Patent No. 5952878.


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